Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene

  title={Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene},
  author={Jian Zuo and Philip L. De Jager and Kanji A. Takahashi and Weining Jiang and David E. J. Linden and Nathaniel Heintz},
Lurcher (Lc) is a spontaneous, semidominant mouse neurological mutation. Heterozygous Lurcher mice (Lc/+) display ataxia as a result of a selective, cell-autonomous and apoptotic death of cerebellar Purkinje cells during postnatal development. Homozygous Lurcher mice (Lc/Lc) die shortly after birth because of a massive loss of mid- and hindbrain neurons during late embryogenesis. We have used positional cloning to identify the mutations responsible for neurodegeneration in two independent Lc… CONTINUE READING
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