Neurodegeneration Is Associated to Changes in Serum Insulin-like Growth Factors

  title={Neurodegeneration Is Associated to Changes in Serum Insulin-like Growth Factors},
  author={Svetlana Busiguina and Ana M. Fernandez and Vicente Barrios and Ruth Clark and Ignacio Torres-Aleman},
  journal={Neurobiology of Disease},
Serum levels of insulin and insulin-like growth factors and their binding proteins (IGFs and IGFBPs, respectively) are changed in human neurodegenerative diseases of very different etiology, such as Alzheimer's disease, amyotrophic lateral sclerosis, or cerebellar ataxia. However, the significance of these endocrine disturbances is not clear. We now report that in two very different inherited neurodegenerative conditions, ataxia-telangiectasia (AT) and Charcot-Marie-Tooth 1A (CMT-1A) disease… CONTINUE READING


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