Neurodegeneration Caused by Trimethyltin via Inhibition of Tropomyosin-receptor-kinase B and Phosphoinositide 3-kinase/protein Kinase B Signaling Cascade

Abstract

Email : tranyen73@gmail.com ABSTRACT Trimethyltin (TMT, 2.4mg/kg, i.p) can trigger neuronal damage by inhibiting Tropomyosin receptor kinase B (TrkB receptor) following by phosphoinositide 3-kinase (PI3K)/protein kinase B or Akt signaling cascade. We examined hippocampal changes in TrkA/B phosphorylation on Tyr490/Tyr516 of TMTtreated mice in a time… (More)

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