Neurodegeneration: Brain strains


patterns of GISTs from patients and found a strong divergence between SDH-deficient GISTs and GISTs that still expressed functional SDH. The SDH-deficient GISTs had greater amounts of genomic hypermethylation compared with the other tumor types, which the authors attributed to defective maintenance of epigenetic marks. Notably, this nonrandom pattern of epigenomic changes in SDH-deficient GISTs correlated with lower genomic stability compared to SDH-proficient tumors, and it is also present in other tumor types characterized by SDH deficiency. These results provide a link between mitochondrial function and epigenomic homeostasis that may have further implications for cancer etiopathology. —VA

DOI: 10.1038/nm.3308

Cite this paper

@article{Silva2013NeurodegenerationBS, title={Neurodegeneration: Brain strains}, author={Kevin Da Silva}, journal={Nature Medicine}, year={2013}, volume={19}, pages={981-981} }