Neurodegeneration: linking ubiquitin/proteasome pathway impairment with inflammation.

  title={Neurodegeneration: linking ubiquitin/proteasome pathway impairment with inflammation.},
  author={Zongmin Li and Marlon Jansen and Sha-Ron Pierre and Maria E Figueiredo-Pereira},
  journal={The international journal of biochemistry & cell biology},
  volume={35 5},
Neurodegenerative disorders have been reported to be associated with accumulation of ubiquitinated proteins in neuronal inclusions and also with signs of inflammation. In these disorders, the abnormal protein aggregates may, themselves, trigger the expression of inflammatory mediators, such as, cyclooxygenase 2 (COX-2). Impairment of the ubiquitin/proteasome pathway may contribute to this neurodegenerative process. Accordingly, proteasome inhibitors and oxidative stressors such as cadmium, were… CONTINUE READING