Neurodegeneration: A question of balance

@article{Thompson2008NeurodegenerationAQ,
  title={Neurodegeneration: A question of balance},
  author={Leslie M. Thompson},
  journal={Nature},
  year={2008},
  volume={452},
  pages={707-708}
}
When a disease-associated gene is mutated, is the cellular activity of its protein product enhanced or reduced? For at least one neurodegenerative disease, spinocerebellar ataxia 1, the answer seems to be both. 
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