Neurocognitive function as an endophenotype for genetic studies of bipolar affective disorder

@article{Savitz2005NeurocognitiveFA,
  title={Neurocognitive function as an endophenotype for genetic studies of bipolar affective disorder},
  author={Jonathan Savitz and Mark Solms and Rajkumar Sewcharan Ramesar},
  journal={NeuroMolecular Medicine},
  year={2005},
  volume={7},
  pages={275-286}
}
The genetic basis of bipolar affective disorder remains opaque despite years of intensive investigation. One of the most serious difficulties for genetic research is the enormous phenotypic heterogeneity of psychiatric illnesses. As a response to this problem, geneticists have searched for alternative strategies to identify those individuals at genetic risk for developing the disorder. One approach is to use endophenotypes or intermediate traits. Gottesman and Gould (2003), in their discussion… CONTINUE READING

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