Neurocognitive evidence for revision of treatment targets and guidelines for phenylketonuria.

@article{Jahja2014NeurocognitiveEF,
  title={Neurocognitive evidence for revision of treatment targets and guidelines for phenylketonuria.},
  author={Rianne Jahja and Stephan C. J. Huijbregts and Leo M J de Sonneville and Jaap J. van der Meere and Francjan J van Spronsen},
  journal={The Journal of pediatrics},
  year={2014},
  volume={164 4},
  pages={
          895-899.e2
        }
}
OBJECTIVES To compare the neurocognitive outcomes of patients with phenylketonuria (PKU) to determine whether decreasing phenylalanine (Phe) levels to <240 is preferable to the use of 360 μmol/L as an upper-target Phe level. An additional aim was to establish the influence of biochemical indices other than Phe on neurocognitive outcomes. STUDY DESIGN Patients with PKU (n = 63; mean age 10.8 ± 2.3 years) and healthy controls (n = 73; mean age 10.9 ± 2.2 years) performed computerized tasks… CONTINUE READING
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