Neurocognitive effects of kava (Piper methysticum): a systematic review

@article{Laporte2011NeurocognitiveEO,
  title={Neurocognitive effects of kava (Piper methysticum): a systematic review},
  author={E Laporte and Jerome Sarris and Con Stough and Andrew Scholey},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={2011},
  volume={26}
}
Kava (Piper methysticum) elicits dose‐dependent psychotropic effects and thus may potentially deleteriously affect cognitive performance. Clinical trials have assessed the effects of kava on cognition, however, to our knowledge no systematic review has been conducted in this area. 
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The Pharmacology, Pharmacokinetics, Efficacy, and Adverse Events Associated With Kava
  • C. White
  • Medicine
    Journal of clinical pharmacology
  • 2018
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Does a Medicinal Dose of Kava Impair Driving? A Randomized, Placebo-Controlled, Double-Blind Study
TLDR
A medicinal dose of kava containing 180 mg of kavalactones does not impair driving ability, whereas 30 mg of oxazepam shows some impairment, and research assessing larger recreational doses of kva on driving ability should now be conducted.
Cases of Kava Impairment in Iowa Drivers
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Indicators of impairment from multiple drug categories, central nervous system (CNS) depressants, CNS stimulants, and cannabis were observed, which may be consistent with the presence of multiple kavalactones and their diverse array of mechanisms of action.
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References

SHOWING 1-10 OF 59 REFERENCES
POSITIVE INTERACTION OF ETHANOL AND KAVA RESIN IN MICE
1. The lipid soluble extract of the psychoactive beverage kava has hypnosedative properties which can be measured by the length of time that the righting reflex is lost.
Saccade and Cognitive Function in Chronic Kava Users
TLDR
Current and ex-kava users showed a higher rate of kava dermopathy, lower body mass index, lowered blood lymphocytes and, in addition, current kavausers showed elevated liver enzymes, while there has recently been increasing concern about potentially fatal liver damage attributed to kava use.
Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava‐kava)
TLDR
Kava is a potent anxiolytic agent, which can facilitate cognitive functioning and can increase positive affectivity related to exhilaration, and unlike conventional benzodiazepine‐type anxIOlytics, which tend to impair cognitive performance and to increase the occurrence of negative affective states.
The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum
TLDR
The aqueous Kava preparation produced significant anxiolytic and antidepressant activity and raised no safety concerns at the dose and duration studied, and appears equally effective in cases where anxiety is accompanied by depression.
Efficacy of kava extract for treating anxiety: systematic review and meta-analysis.
TLDR
The meta-analysis of three trials suggests a significant difference in the reduction of the total score on the Hamilton Rating Scale for Anxiety in favor of kava Extract, implying that kava extract is superior to placebo as a symptomatic treatment for anxiety.
Pharmacopsychological effects of oxazepam and kava-extract in a visual search paradigm assessed with event-related potentials.
The effects of oxazepam and a standardized extract of kava-roots (WS1490, W. Schwabe, Karlsruhe) on reaction time and event-related potentials (ERPs) were investigated in a visual search paradigm
A Systematic Review of the Safety of Kava Extract in the Treatment of Anxiety
TLDR
When taken as a short-term monotherapy at recommended doses, kava extracts appear to be well tolerated by most users, and a possible interaction with benzodiazepines has been reported.
The Kava Anxiety Depression Spectrum Study (KADSS): A randomized, placebo-controlled, cross-over trial using an aqueous extract of Piper methysticum
TLDR
The aqueous Kava preparation produced significant anxiolytic and antidepressant activity and raised no safety concerns at the dose and duration studied, and appears equally effective in cases where anxiety is accompanied by depression.
EEG‐Brain mapping, psychometric and psychophysiological studies on central effects of kavain ‐ a kava plant derivative
TLDR
Brain maps of drug induced pharmaco‐EEG changes demonstrated that kavain exerted a significant action on the human brain function as compared with placebo characterized by a dose‐dependent increase of delta, theta and alpha 1 activity while alpha 2, beta activity and the centroid of the total activity decreased.
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