Neurocircuitry of illness-induced hyperalgesia.

  title={Neurocircuitry of illness-induced hyperalgesia.},
  author={Linda R. Watkins and Eric P. Wiertelak and Lisa Elane Goehler and K Mooney-Heiberger and Jennifer V. Martinez and L E Furness and Kathleen Smith and Steven F. Maier},
  journal={Brain research},
  volume={639 2},
We have previously demonstrated that illness-inducing agents such as lithium chloride (LiCl) and the bacterial cell wall endotoxin lipopolysaccharide (LPS) produce hyperalgesia on diverse pain measures. The present series of studies attempted to identify the neurocircuitry mediating these effects. These studies have demonstrated that illness-inducing agents produce hyperalgesia by activating: (a) peripheral nerves rather than by generating a blood-borne mediator (Expt. 1); (b) vagal afferents… CONTINUE READING


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