Neurochemistry and neuropharmacology of emesis - the role of serotonin.

@article{Endo2000NeurochemistryAN,
  title={Neurochemistry and neuropharmacology of emesis - the role of serotonin.},
  author={Toru Endo and Masaru Minami and Masahiko Hirafuji and Toru Ogawa and Keiichi Akita and Masahiro Nemoto and Hideya Saito and Mitsuhiro Yoshioka and Syed Hasan Parvez},
  journal={Toxicology},
  year={2000},
  volume={153 1-3},
  pages={189-201}
}
Emesis is an instinctive defense reaction caused by the somato-autonomic nerve reflex which is integrated in the medulla oblongata. Emesis caused by cytotoxic drugs and radiation is associated with an increase in the concentration of 5-hydroxytryptamine (5-HT) in the intestinal mucosa and in the brainstem. 5-HT released from enterochromaffin (EC) cells, which synthesize and secrete 5-HT, stimulates the 5-HT(3) receptors on the adjacent vagal afferent nerves. This vagal afferent nerve… CONTINUE READING

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