Neurochemical mechanisms underlying alcohol withdrawal.

@article{Littleton1998NeurochemicalMU,
  title={Neurochemical mechanisms underlying alcohol withdrawal.},
  author={John Martin Littleton},
  journal={Alcohol health and research world},
  year={1998},
  volume={22 1},
  pages={13-24}
}
More than 50 years ago, C.K. Himmelsbach first suggested that physiological mechanisms responsible for maintaining a stable state of equilibrium (i.e., homeostasis) in the patient's body and brain are responsible for drug tolerance and the drug withdrawal syndrome. In the latter case, he suggested that the absence of the drug leaves these same homeostatic mechanisms exposed, leading to the withdrawal syndrome. This theory provides the framework for a majority of neurochemical investigations of… CONTINUE READING

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Alcohols and neurotransmitter gated ion channels: past, present and future

Naunyn-Schmiedeberg's Archives of Pharmacology • 1997
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