Neurochemical investigation of the schizophrenic brain by in vivo phosphorus magnetic resonance spectroscopy.

@article{Fukuzako2001NeurochemicalIO,
  title={Neurochemical investigation of the schizophrenic brain by in vivo phosphorus magnetic resonance spectroscopy.},
  author={Hiroshi Fukuzako},
  journal={The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry},
  year={2001},
  volume={2 2},
  pages={70-82}
}
  • Hiroshi Fukuzako
  • Published 2001 in
    The world journal of biological psychiatry : the…
Abnormal phospholipid metabolisms may play important roles in the pathophysiology of schizophrenia. Phosphorus magnetic resonance spectroscopy (31P-MRS) offers a new method for studying phosphorus-related metabolism in vivo. A decrease in the level of phosphomonoesters (PME) and an increase in the level of phosphodiesters (PDE) has been demonstrated in the prefrontal lobe of neuroleptic-naive schizophrenic patients. Most of the studies in medicated schizophrenic patients have shown decreased… CONTINUE READING
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