Neurochemical evidence that supraspinally administered gabapentin activates the descending noradrenergic system after peripheral nerve injury.

@article{Takeuchi2007NeurochemicalET,
  title={Neurochemical evidence that supraspinally administered gabapentin activates the descending noradrenergic system after peripheral nerve injury.},
  author={Yuichi Takeuchi and Keiko Takasu and Motoko Honda and Hideki Ono and Mitsuo Tanabe},
  journal={European journal of pharmacology},
  year={2007},
  volume={556 1-3},
  pages={69-74}
}
We have previously demonstrated that gabapentin supraspinally activates the descending noradrenergic system to produce analgesic effects after peripheral nerve injury. To further establish the neurochemical basis for its supraspinally mediated analgesic action, concentrations of spinal noradrenaline, 4-hydroxy-3-methoxyphenylglycol (MHPG), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and dopamine were measured using high-performance liquid chromatography in a murine neuropathic pain… CONTINUE READING

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