Neurochemical evidence for the release of acetylcholine from the guinea-pig ileum myenteric plexus by capsaicin.

@article{Barth1985NeurochemicalEF,
  title={Neurochemical evidence for the release of acetylcholine from the guinea-pig ileum myenteric plexus by capsaicin.},
  author={L{\'o}r{\'a}nd Barth{\'o} and E. Sylvester Vizi},
  journal={European journal of pharmacology},
  year={1985},
  volume={110 1},
  pages={125-7}
}
Superfusion of the sensory stimulant drug capsaicin (3.3 microM) released [3H]acetylcholine from isolated myenteric plexus-longitudinal muscle strips of guinea-pig ileum, preincubated with [3H]choline. This effect was prevented by tetrodotoxin. There was a fast tachyphylaxis to the effect of capsaicin. It is suggested that capsaicin-sensitive nerve endings capable of activating intrinsic cholinergic neurones are situated in the myenteric plexus of the guinea-pig ileum. 

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