Neurochemical evidence for antagonism by olanzapine of dopamine, serotonin, α1-adrenergic and muscarinic receptors in vivo in rats

@article{Bymaster1996NeurochemicalEF,
  title={Neurochemical evidence for antagonism by olanzapine of dopamine, serotonin, α1-adrenergic and muscarinic receptors in vivo in rats},
  author={Frank P. Bymaster and Susan K. Hemrick-Luecke and Kenneth Perry and Ray W. Fuller},
  journal={Psychopharmacology},
  year={1996},
  volume={124},
  pages={87-94}
}
The ability of the atypical antipsychotic drug candidate olanzapine to antagonize dopamine, serotonin, α-adrenergic and muscarinic receptors in vivo was assessed by various neurochemical measurements in rat brain. Olanzapine increased the concentrations of the dopamine metabolites DOPAC and HVA in striatum and nucleus accumbens. Olanzapine antagonized the pergolide-induced decrease of striatal DOPA concentrations in rats treated with gammabutyrolactone and NSD1015 and increased striatal 3… CONTINUE READING

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