Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo

@article{Rao1990NeurochemicalCO,
  title={Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo
},
  author={Tadimeti S Rao and Julie A. Cler and Steven J. Mick and V. M. Dilworth and Patricia C. Contreras and Smriti Iyengar and Paul L. Wood},
  journal={Neuropharmacology},
  year={1990},
  volume={29},
  pages={1191-1197}
}
  • T. Rao, J. Cler, P. Wood
  • Published 1 December 1990
  • Biology, Chemistry, Medicine
  • Neuropharmacology
Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats.
The aim of the present study was to examine the effect of combined treatment of male Wistar rats with pramipexole and fluoxetine or sertraline in the forced swimming test. The obtained results showed
[Update Opipramol].
TLDR
In view of the limited availability of (pharmacologic) treatment options for generalized anxiety disorder and particularly somatoform disorders, opipramol should be considered in the treatment of these entities.
Current hypotheses on sigma receptors and their physiological role: possible implications in psychiatry.
  • G. Debonnel
  • Psychology, Biology
    Journal of psychiatry & neuroscience : JPN
  • 1993
TLDR
Evidence suggests that sigma receptors could be involved in the pathophysiology and/or in the treatment of schizophrenia by modulating the glutamatergic inputs, by regulating directly the firing activity of dopaminergic neurons, or by both mechanisms.
The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism
TLDR
BMY-14802 exerts its AIM-suppressing effects via a 5-HT1A agonist mechanism, similar to buspirone, which is a promising candidate for clinical trials due to its extremely low affinity for the D2 receptor and lack of extrapyramidal effects during prior clinical trials for schizophrenia.
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