Neurochemical basis of cannabis addiction

@article{Maldonado2011NeurochemicalBO,
  title={Neurochemical basis of cannabis addiction},
  author={Rafael Maldonado and Fernando Berrendero and Andr{\'e}s Ozaita and Patricia Robledo},
  journal={Neuroscience},
  year={2011},
  volume={181},
  pages={1-17}
}
Cannabis derivatives have become the most widely used illicit substances in developed countries, and constitute a major health concern. The psychoactive compounds contained in cannabis induce their pharmacological effects by the activation of at least two different receptors, CB1 and CB2 cannabinoid receptors. Multiple studies have demonstrated the specific involvement of CB1 cannabinoid receptors in the addictive properties of cannabinoids. Several neurotransmitter systems involved in the… 
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