Neurochemical and electrophysiological evidence for the existence of a functional γ-hydroxybutyrate system in NCB-20 neurons

@article{Kemmel1998NeurochemicalAE,
  title={Neurochemical and electrophysiological evidence for the existence of a functional γ-hydroxybutyrate system in NCB-20 neurons},
  author={V{\'e}ronique Kemmel and O. Taleb and A. P{\'e}rard and C. Andriamampandry and M. Maitre},
  journal={Neuroscience},
  year={1998},
  volume={86},
  pages={989-1000}
}
  • Véronique Kemmel, O. Taleb, +2 authors M. Maitre
  • Published 1998
  • Biology, Medicine
  • Neuroscience
  • Clonal neurohybridoma NCB-20 cells express a valproate-insensitive succinic semialdehyde reductase activity that transforms succinic semialdehyde into gamma-hydroxybutyrate. This activity (1.14+/-0.16 nmol/min/mg protein) was similar to the lowest activity existing in adult rat brain. [3H]gamma-Hydroxybutyrate labels a homogeneous population of sites on NCB-20 cell membranes (Kd=250+/-44.4nM, Bmax=180+/-16.2fmol/mg protein) that apparently represents specific gamma-hydroxybutyrate binding sites… CONTINUE READING
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