• DOI:10.1016/S0306-4522(98)00085-2
Corpus ID: 21001043

Neurochemical and electrophysiological evidence for the existence of a functional γ-hydroxybutyrate system in NCB-20 neurons

@article{Kemmel1998NeurochemicalAE,
  title={Neurochemical and electrophysiological evidence for the existence of a functional γ-hydroxybutyrate system in NCB-20 neurons},
  author={V{\'e}ronique Kemmel and O. Taleb and A. P{\'e}rard and C. Andriamampandry and M. Maitre},
  journal={Neuroscience},
  year={1998},
  volume={86},
  pages={989-1000}
}

Véronique Kemmel, O. Taleb, +2 authors M. Maitre

Published 1998

Biology, Medicine

Neuroscience

Clonal neurohybridoma NCB-20 cells express a valproate-insensitive succinic semialdehyde reductase activity that transforms succinic semialdehyde into gamma-hydroxybutyrate. This activity (1.14+/-0.16 nmol/min/mg protein) was similar to the lowest activity existing in adult rat brain. [3H]gamma-Hydroxybutyrate labels a homogeneous population of sites on NCB-20 cell membranes (Kd=250+/-44.4nM, Bmax=180+/-16.2fmol/mg protein) that apparently represents specific gamma-hydroxybutyrate binding sites… CONTINUE READING

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