Neurochemical and behavioural investigations of the NMDA receptor-associated glycine site in the rat striatum: Functional implications for treatment of parkinsonian symptoms

@article{Carroll1995NeurochemicalAB,
  title={Neurochemical and behavioural investigations of the NMDA receptor-associated glycine site in the rat striatum: Functional implications for treatment of parkinsonian symptoms},
  author={Camille B Carroll and Victoria Holloway and Jonathan Michael Brotchie and Ian John Mitchell},
  journal={Psychopharmacology},
  year={1995},
  volume={119},
  pages={55-65}
}
The glutamatergic cortico-striatal and subthalamo-entopeduncular pathways are both overactive in parkinsonism. Previous behavioural investigations have shown that intra-entopeduncular injection of either NMDA-site or glycine-site antagonists results in alleviation of parkinsonian symptoms, although injection of the former is associated with the appearance of anaesthetic-like side effects. These behavioural differences may be mediated by action on different NMDA receptor subtypes. Recent… CONTINUE READING

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