Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers

@article{Boer1988NeurochemicalAA,
  title={Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers},
  author={Thijs de Boer and Guido Maura and Maurizio Raiteri and Clazien J. de Vos and Johannus H. Wieringa and Roger Martin Pinder},
  journal={Neuropharmacology},
  year={1988},
  volume={27},
  pages={399-408}
}
The neurochemical and autonomic pharmacological profile of 1,2,3,4,10, 14b-hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c]pyrido[2, 3-c] [2] benzazepine [+/-)Org 3770) and the related antidepressant drug, mianserin, have been compared. The uptake of [3H]noradrenaline ([3H]NA) in vitro was weakly affected by (+/-)Org 3770 (pKi = 5.6) in contrast to mianserin (pKi = 7.4). Both (+/-)Org 3770 and mianserin facilitated the release of [3H]NA in slices of cortex. The effects of NA mediated by alpha 2… Expand
The α2-adrenoceptor antagonist Org 3770 enhances serotonin transmission in vivo
Abstract The antidepressant properties of Org 3770 (1,2,3,4,10,14b-hexahydro-2-methylpyrazinol[2,1-a]pyridol[2,3-c][2]benzazepine) may be mediated via blockade of auto and hetero α2-adrenoceptors.Expand
Neurochemical effects of the enantiomers of mirtazapine in normal rats.
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Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells
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The results indicate that the two enantiomers block the 5-HT3 receptor-mediated ion current in a mutually dependent manner. Expand
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Interaction ORG3770 between Enantiomers of Mianserin and at 5-HT3 Receptors in Cultured Mouse Neuroblastoma Cells
Summary--Stereoselective effects of mianserin and ORG3770 on serotonin 5-HT3 receptors in mouse neuroblastoma N1E-115 cells have been investigated in radioligand binding and in whole-cell voltageExpand
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Several chemically unrelated agents has been developed and introduced in the past decade, to supplement the earlier antidepressants, as well as drugs with distinct neurochemical profiles such as mirtazapine, nefazodone, moclobemide and tianeptine, which may explain the individual variability with all these drugs. Expand
The Selective α2-Adrenoceptor Antagonist Mirtazapine (Org 3770) Enhances Noradrenergic and 5-HT1A-Mediated Serotonergic Neurotransmission
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The tonic activation of postsynaptic 5-HT receptors is enhanced by a 21-day treatment with mirtazapine, as a result of a sustained increase in5-HT neuron firing activity in the presence of decreased function of α2-adrenergic heteroreceptors located on 5- HT terminals in the dorsal hippocampus. Expand
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Binding sites with high affinity and specificity for [(3)H]quinuclidinyl benzilate (QNB) are present in homogenates of rat brain. The characteristics of the binding sites resemble those of muscarinicExpand
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