Neurochemical alterations induced by manganese chloride in neonatal rats.

  title={Neurochemical alterations induced by manganese chloride in neonatal rats.},
  author={R L Deskin and Steven J Bursian and Frank W. Edens},
  volume={2 1},
Male rats were exposed to manganese at doses of 1, 10, and 20 microg/g body weight/day from birth to day 24 post-partum. Animals were weighed and examined daily. The animals showed no visible signs of toxicity and exhibited normal weight gain. On day 25 the animals were killed by decapitation and the hypothalamic area and corpus striatum were removed and analyzed for several neurochemical components. Chronic manganese administration (10 and 20 microg/g) caused a significant reduction in the… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 19 extracted citations

Action of Manganese on Puberty

View 8 Excerpts
Highly Influenced

Manganese induces IGF-1 and cyclooxygenase-2 gene expressions in the basal hypothalamus during prepubertal female development.

Toxicological sciences : an official journal of the Society of Toxicology • 2011
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…