Neurochemical alterations induced by manganese chloride in neonatal rats.

@article{Deskin1981NeurochemicalAI,
  title={Neurochemical alterations induced by manganese chloride in neonatal rats.},
  author={R L Deskin and Steven J Bursian and Frank W. Edens},
  journal={Neurotoxicology},
  year={1981},
  volume={2 1},
  pages={65-73}
}
Male rats were exposed to manganese at doses of 1, 10, and 20 microg/g body weight/day from birth to day 24 post-partum. Animals were weighed and examined daily. The animals showed no visible signs of toxicity and exhibited normal weight gain. On day 25 the animals were killed by decapitation and the hypothalamic area and corpus striatum were removed and analyzed for several neurochemical components. Chronic manganese administration (10 and 20 microg/g) caused a significant reduction in the… CONTINUE READING

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