Neurochemical alteration in the caudate: implications for the pathophysiology of bipolar disorder.

@article{Shahana2011NeurochemicalAI,
  title={Neurochemical alteration in the caudate: implications for the pathophysiology of bipolar disorder.},
  author={Nasrin Shahana and Melissa P. Delbello and W J Chu and Kelly Jarvis and David Fleck and Jeffrey A. Welge and Stephen M Strakowski and Caleb M. Adler},
  journal={Psychiatry research},
  year={2011},
  volume={193 2},
  pages={107-12}
}
Several lines of evidence suggest that the neuropathophysiology of bipolar disorder is marked by structural and functional abnormalities in the caudate. We used magnetic resonance spectroscopy imaging (MRSI) to examine potential neurochemical changes in the caudate of adult bipolar patients (BP). 2D-MRSI scans including the caudate were obtained from 25 BP and 9 healthy subjects (HS). BP patients were further divided into medicated (n=14) and unmedicated (n=11) groups; the majority of medicated… CONTINUE READING