Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice

@article{Fox2008NeurochemicalBA,
  title={Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice},
  author={Meredith A. Fox and Catherine L. Jensen and Helen T. French and Alison R. Stein and Su-Jan Huang and Teresa J. Tolliver and Dennis L. Murphy},
  journal={Psychopharmacology},
  year={2008},
  volume={201},
  pages={203-218}
}
Serotonin transporter (SERT) knockout (−/−) mice have an altered phenotype in adulthood, including high baseline anxiety and depressive-like behaviors, associated with increased baseline extracellular serotonin levels throughout life. To examine the effects of increases in serotonin following the administration of the serotonin precursor 5-hydroxy-l… CONTINUE READING