Neuroblastomas have distinct genomic DNA profiles that predict clinical phenotype and regional gene expression.

@article{Mosse2007NeuroblastomasHD,
  title={Neuroblastomas have distinct genomic DNA profiles that predict clinical phenotype and regional gene expression.},
  author={Yael Mosse and Sharon J. Diskin and Nora F. Wasserman and Katherine L Rinaldi and Edward F. Attiyeh and Kristina Cole and Jayanti Jagannathan and Karishma Bhambhani and Cynthia Winter and John M. Maris},
  journal={Genes, chromosomes & cancer},
  year={2007},
  volume={46 10},
  pages={936-49}
}
Neuroblastoma is a heterogeneous neoplasm that has served as a paradigm for the clinical utility of somatically acquired genomic aberrations. DNA copy number alterations (CNA) are currently used to predict prognosis, including MYCN amplification and deletions at chromosome bands 1p36 and 11q23. We predicted that genome-wide assessment of DNA aberrations in neuroblastoma tumors would provide a more precise estimation of clinical phenotype, and could be used to predict outcome. We measured CNAs… CONTINUE READING