Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis

@article{Negroni2000NeuroblastomaSE,
  title={Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis},
  author={Anna Negroni and D. Venturelli and Barbara Tanno and Roberto Amendola and St{\'e}phane Ransac and Vincenzo Cesi and Bruno Calabretta and Giuseppe Raschell{\'a}},
  journal={Cell Death and Differentiation},
  year={2000},
  volume={7},
  pages={843-850}
}
DR-nm23 belongs to a gene family which includes nm23-H1, originally identified as a candidate metastasis suppressor gene. Nm23 genes are expressed in different tumor types where their levels have been alternatively associated with reduced or increased metastatic potential. Nm23-H1, -H2, DR-nm23 and nm23-H4 all possess NDP kinase activity. Overexpression of DR-nm23 inhibits differentiation and promotes apoptosis in hematopoietic cells. By contrast, it induces morphological and biochemical… CONTINUE READING