Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation

@article{Edsj2004NeuroblastomaCW,
  title={Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation},
  author={Anders Edsj{\"o} and Hel{\'e}n {\AA}. Nilsson and Jo Vandesompele and Jenny Karlsson and Filip Pattyn and Lloyd A. Culp and Frank Speleman and Sven P{\aa}hlman},
  journal={Laboratory Investigation},
  year={2004},
  volume={84},
  pages={406-417}
}
Amplification of MYCN in neuroblastoma strongly correlates to unfavorable outcome, but little is known of how the high MYCN expression translates into an aggressive tumor phenotype. More aggressive neuroblastomas are generally immature and overexpression of exogenous MYCN in cultured neuroblastoma cells and other neuronal cell types has been reported to inhibit induced differentiation, suggesting a link between high MYCN expression and an immature phenotype. However, we show here that MYCN is… CONTINUE READING

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