Neuroblastoma cell detection by reverse transcriptase-polymerase chain reaction (RT-PCR) for tyrosine hydroxylase mRNA.

@article{Burchill1994NeuroblastomaCD,
  title={Neuroblastoma cell detection by reverse transcriptase-polymerase chain reaction (RT-PCR) for tyrosine hydroxylase mRNA.},
  author={Susan Ann Burchill and F M Bradbury and Brad K. Smith and Ian J. Lewis and Peter John Selby},
  journal={International journal of cancer},
  year={1994},
  volume={57 5},
  pages={671-5}
}
The presence of tumour cells in peripheral blood of neuroblastoma patients is of considerable clinical importance. Nucleic acid amplification offers an opportunity to detect very small numbers of such cells, but in neuroblastoma a frequent specific abnormality in the tumour DNA suitable for this purpose has yet to be identified. To facilitate the detection of such cells we have developed RT-PCR using tyrosine hydroxylase (TH) as a tissue-specific target gene. TH mRNA was detected in 3… CONTINUE READING
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