Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts

@inproceedings{PalaciosMoreno2015NeuroblastomaTK,
  title={Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts},
  author={Juan Manuel Palacios-Moreno and Lauren Foltz and Ailan Guo and Matthew P. Stokes and Emily D. Kuehn and Lynn George and Michael Comb and Mark L. Grimes},
  booktitle={PLoS Computational Biology},
  year={2015}
}
Protein phosphorylation plays a central role in creating a highly dynamic network of interacting proteins that reads and responds to signals from growth factors in the cellular microenvironment. Cells of the neural crest employ multiple signaling mechanisms to control migration and differentiation during development. It is known that defects in these mechanisms cause neuroblastoma, but how multiple signaling pathways interact to govern cell behavior is unknown. In a phosphoproteomic study of… CONTINUE READING
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