Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts

  title={Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts},
  author={Juan Palacios-Moreno and Lauren Foltz and A. Guo and Matthew P. Stokes and Emily D. Kuehn and L. George and M. Comb and M. Grimes},
  journal={PLoS Computational Biology},
  • Juan Palacios-Moreno, Lauren Foltz, +5 authors M. Grimes
  • Published 2015
  • Biology, Computer Science, Medicine
  • PLoS Computational Biology
  • Protein phosphorylation plays a central role in creating a highly dynamic network of interacting proteins that reads and responds to signals from growth factors in the cellular microenvironment. Cells of the neural crest employ multiple signaling mechanisms to control migration and differentiation during development. It is known that defects in these mechanisms cause neuroblastoma, but how multiple signaling pathways interact to govern cell behavior is unknown. In a phosphoproteomic study of… CONTINUE READING
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