Neuroblastoma

@article{Maris2007Neuroblastoma,
  title={Neuroblastoma},
  author={John M. Maris and Michael D. Hogarty and Rochelle Bagatell and Susan L. Cohn},
  journal={The Lancet},
  year={2007},
  volume={369},
  pages={2106-2120}
}
Neuroblastoma is a type of cancer that most often affects children. Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor. Most commonly, the tumor originates in the nerve tissue of the adrenal gland located above each kidney. Other common sites for tumors to form include the nerve tissue in the abdomen, chest, neck, or pelvis. Neuroblastoma can spread (metastasize) to other parts of the body such as the bones, liver, or… Expand

Figures and Tables from this paper

Neuroblastoma: A Case of Massive Hepatomegaly
TLDR
There needs to be more research on the optimum treatment modality for patients with Stage 4S disease and massive hepatomegaly to improve patient outcomes. Expand
Neuroblastoma of the lumbar spine.
TLDR
The case of a healthy 34-year-old man treated for a large neuroblastoma involving the L3-5 vertebral bodies and prevertebral great vessels, which remains alive with stable disease more than 2-years after his initial diagnosis. Expand
Neuroblastoma and MYCN.
  • M. Huang, W. Weiss
  • Biology, Medicine
  • Cold Spring Harbor perspectives in medicine
  • 2013
TLDR
Roles for MYCN in neuroblastoma are reviewed and recent identification of other driver mutations are highlighted, as well as strategies to target MYCN at the level of protein stability and transcription. Expand
Surgical Management of Giant L2 Adrenal Neuroblastoma in Adult Male
TLDR
This work presents here the surgical management of the rare adult adrenal neuroblastoma, a 35-year-old male patient presented with a giant nonfunctional left adrenal mass and underwent en-bloc surgical excision of theleft adrenal gland along with the left kidney. Expand
Metastatic Spread of Neuroblastoma to the Left Atrium Mimicking Atrial Myxoma: A Rare Occurrence in an Adolescent
TLDR
A case of a 12-year-old male child who was misdiagnosed as a case of cardiac myxoma on initial presentation is reported, which highlights the differential diagnosis for the cardiac mass in an adolescent with an unknown primary origin and also the importance of tissue histopathology for the diagnosis and management of neuroblastoma. Expand
Staged resection of a bilateral thoracic and bilateral adrenal neuroblastoma
TLDR
A rare case of bilateral thoracic and adrenal GN and GNBI in a 5-year-old boy and no recurrence was found during a 2-year follow-up. Expand
Neuroblastoma—A Neural Crest Derived Embryonal Malignancy
TLDR
Factors and processes within the neural crest that when dysregulated have the potential to be initiators or drivers of neuroblastoma development are discussed and will give valuable information for the development of medicines that specifically target molecules within Neuroblastoma cells. Expand
Neonatal Neuroblastoma.
TLDR
The epidemiology, treatment options, and anticipated outcomes for neonatal neuroblastoma are discussed, including using a watch-and-wait approach for patients at low risk for disease progression/relapse. Expand
Extra-Adrenal Adult Neuroblastoma With Aberrant Germ Cell Marker Expression: Maturation After Chemotherapy as an Important Clue to a Challenging Diagnosis
TLDR
A very unusual case of a Schwannian stroma-poor adult neuroblastoma of inguinal location, showing aberrant expression of germ cell markers: SALL4 and OCT4, which added an important clue for the final diagnosis. Expand
PPARγ in Neuroblastoma
TLDR
The role and the possible mechanism(s) of action) of PPARγ in NB cells are reviewed and agonists of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) have been shown to have pleiotropic effects, including antineoplastic effects. Expand
...
1
2
3
4
5
...

References

SHOWING 1-8 OF 8 REFERENCES
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
Neuroblastoma, a tumour derived from the peripheral sympathetic nervous system, is one of the most frequent solid tumours in childhood. It usually occurs sporadically but familial cases are observed,Expand
Identification of ALK as a major familial neuroblastoma predisposition gene
TLDR
It is demonstrated that heritable mutations of ALK are the main cause of familial neuroblastoma, and that germline or acquired activation of this cell-surface kinase is a tractable therapeutic target for this lethal paediatric malignancy. Expand
Prevalence and functional consequence of PHOX2B mutations in neuroblastoma
TLDR
The findings show that PHOX2B alterations are a rare cause of hereditary neuroblastoma, but disruption of this neurodevelopmental pathway can interfere with transcription-dependent terminal differentiation. Expand
Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma
TLDR
Results suggest that one or more genes involved in neuroblastoma tumorigenesis or tumor progression are likely contained within this region of distal chromosome 1p. Expand
KIF 1 Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1 p 36 . 2 by inducing apoptotic cell death
  • J Biol Chem
The kinesin KIF 1 Bbeta acts downstream from EglN 3 to induce apoptosis and is a potential 1 p 36 tumor suppressor
  • Genes Dev