Neuroblastoma—remembering the three physicians who described it a century ago: James Homer Wright, William Pepper, and Robert Hutchison

  title={Neuroblastoma—remembering the three physicians who described it a century ago: James Homer Wright, William Pepper, and Robert Hutchison},
  author={Alexis B. Rothenberg and Walter E. Berdon and Giulio J D'angio and Darrell J. Yamashiro and Robert A. Cowles},
  journal={Pediatric Radiology},
Neuroblastoma is often widespread at the time of diagnosis. Three physicians between 1900 and 1910 played an important role in the pathologic definition of neuroblastoma and its route of spread in relation to the age of the patient. These findings eventually led to the advances in treatment and decreased morbidity of today. In 1910 James Homer Wright was the first to recognize the tumor as being of primitive neural cell origin, calling it neuroblastoma and emphasizing the bundle of cells termed… Expand
Stage 4S Neuroblastoma: A Report of Two Cases Presenting with Extremes of Biological Behavior.
Two cases of stage 4S neuroblastoma exemplifying these two extreme behaviors are reported, including a full-term new born baby who presented with abdominal distention and respiratory distress and a four-month-old baby who initially presented with a thigh lump. Expand
Neuroblastoma in Early Childhood: A Case Report and Literature Review
A rare case of metastasis of neuroblastoma in a 2-year-old child presenting complain of fever for several weeks, anorexia, loss of weight, arthralgia and multiple scalp nodules and inguinal lymph node enlargement is reported. Expand
Neuroblastoma of the elderly, an oncologist’s nightmare: case presentation, literature review and SEER database analysis
A rare and challenging case of an 86-year old patient presenting with mediastinal neuroblastoma and syndrome of inappropriate antidiuretic hormone secretion (SIADH) successfully treated with resection is reported. Expand
Molecular pathogenesis of peripheral neuroblastic tumors
The identification of gene expression signatures associated with patient's outcome points out the potential of using gene expression profiling to improve clinical management of patients suffering from NB and possible evolution/progression schemes in NB. Expand
Neuroblastoma in early childhood: A rare case report and review of literature
A rare case of neuroblastoma in a 3-year-old child presenting classical oral manifestations such as bilateral palatal swelling, rolled border ulcer on the posterior part of hard palate adjacent to primary molars, and bilateral proptosis is reported. Expand
Neuroblastoma and Other Adrenal Tumors
This chapter addresses the medical presentation, histology, biological features, risk stratification, and surgical management of malignant adrenal disease. Neuroblastoma is the most common adrenalExpand
Neuroblastoma in Iraq-KRG-Sulaimani
The stage in this six years prospective study was age dependent but it was neither depending on the sex nor the site of the primary tumor with the stage of neuroblastoma in patients. Expand
Demographic features of neuroblastoma in Iraq-Kurdistan Region- Sulaimani
The stage in this study was age dependent, but it was neither depending on the sex nor the site of the primary tumor, and this in turn has important value in the treatment strategies. Expand
Primitive neuroectodermal tumor of the cervix diagnosed during pregnancy: a rare case report with discussion
  • Xiang Feng, Lina Zhang, +7 authors Hua Li
  • Medicine
  • BMC Pregnancy and Childbirth
  • 2021
PNET during pregnancy is a rare but complex condition that requires an individualized treatment plan according to gestational age, and timely surgical treatment can significantly prolong the survival time of patients but may also lead to fetal loss and the inability to carry a pregnancy. Expand
On the Diagnostics of Neuroblastoma
  • 2018
Georgantzi, K. 2018. On the Diagnostics of Neuroblastoma. Clinical and Experimental Studies. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1514. 50 pp.Expand


Roentgen therapy in neuroblastoma; a review of seventy three cases.
In the neuroblastomas of infancy and childhood the physician is dealing with a multipotential tumor which may be curable. The outcome will in part depend upon the localization of the primary lesion,Expand
James Homer Wright: A Biography of the Enigmatic Creator of the Wright Stain on the Occasion of Its Centennial
He is remembered eponymously by the blood cell stain that bears his name and the Homer Wright pseudorosettes of neuroblastoma, but he made many additional contributions to pathology, including determination of the cellular lineage of multiple myeloma, identification of the megakaryocyte as the cell of origin of blood platelets, and clarification of misconceptions about actinomycosis. Expand
Neuroblastoma sympatheticum; a study and report of 217 cases.
The treatment of patients with neuroblastoma does not lie solely in the province of a single specialty; it requires cooperation of pediatrician, surgeon, radiologist and tumor therapist if optimum results are to be obtained. Expand
Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.
Modifications of the INSS and INRC made at this conference are presented and proposals are made for future modifications in these criteria and for the development of International Neuroblastoma Risk Groups. Expand
  • J. H. Wright
  • Medicine
  • The Journal of experimental medicine
  • 1910
A group of tumors, the nature of which has hitherto escaped general recognition, is called attention, and their distinguishing characteristics are pointed out. Expand
Neuroblastoma: biological insights into a clinical enigma
Recent advances in understanding the biology and genetics of neuroblastomas have allowed classification into low-, intermediate- and high-risk groups, which allows the most appropriate intensity of therapy to be selected — from observation alone to aggressive, multimodality therapy. Expand
A proposed staging for children with neuroblastoma. Children's cancer study group A
Short‐term survival data of this small sample demonstrated that the proposed staging appears to be of help in estimating the prognosis and a list of investigations which aid in accurate staging is proposed. Expand
A study of congenital sarcoma of the liver and suprarenal with report of a case
  • Am J Med Sci
  • 1901