Neurobiology of substance P and the NK1 receptor.

  title={Neurobiology of substance P and the NK1 receptor.},
  author={Patrick W Mantyh},
  journal={The Journal of clinical psychiatry},
  volume={63 Suppl 11},
Substance P belongs to a group of neurokinins (NKs), small peptides that are broadly distributed in the central nervous system (CNS) and peripheral nervous system (PNS). The biological effects of substance P in the CNS, namely regulation of affective behavior and emesis in the brain and nociception in the spinal cord, are mediated by its binding to the NK1 receptor. The substance P-NK1 (SP-NK1) receptor system is the most extensively studied NK pathway, and in contrast to receptors for other… CONTINUE READING