Neurobiology of fibromyalgia syndrome.

  title={Neurobiology of fibromyalgia syndrome.},
  author={Donald D. Price and Roland Staud},
  journal={The Journal of rheumatology. Supplement},
Accumulating evidence suggests that fibromyalgia syndrome (FM) pain is maintained by tonic impulse input from deep tissues, such as muscle and joints, in combination with central sensitization mechanisms. This nociceptive input may originate in peripheral tissues (trauma and infection) resulting in hyperalgesia/allodynia and/or central sensitization. Evidence for abnormal sensitization mechanisms in FM includes enhanced temporal summation of delayed pain in response to repeated heat taps and… CONTINUE READING


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