Neurobiology of addiction. Toward the development of new therapies.

@article{Koob2000NeurobiologyOA,
  title={Neurobiology of addiction. Toward the development of new therapies.},
  author={George F. Koob},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={909},
  pages={
          170-85
        }
}
Drug addiction is a chronic relapsing brain disorder characterized by neurobiological changes that lead to a compulsion to take a drug with loss of control over drug intake. The hypothesis outlined here is that knowledge of the neurochemical systems involved in the transition from drug use to the compulsive use of addiction will provide the rational basis for development of pharmacotherapies for drug addiction. Much evidence has been obtained in identifying the midbrain-basal forebrain neural… CONTINUE READING

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