Neurobiology of Disease EMMPRIN : A Novel Regulator of Leukocyte Transmigration into the CNS in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

@inproceedings{Agrawal2011NeurobiologyOD,
  title={Neurobiology of Disease EMMPRIN : A Novel Regulator of Leukocyte Transmigration into the CNS in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis},
  author={Smriti M. Agrawal and Claudia Silva and Wallace W. Tourtellotte and V. Wee Yong},
  year={2011}
}
Extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a member of the Ig superfamily, with various physiological roles including the induction of matrix metalloproteinases (MMPs), leukocyte activation, and tumor progression. In this study, we illustrate a novel involvement of EMMPRIN in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). We found EMMPRIN levels to be upregulated on peripheral leukocytes before onset of EAE clinical signs… CONTINUE READING
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