Neurobiology of DHEA and effects on sexuality, mood and cognition

  title={Neurobiology of DHEA and effects on sexuality, mood and cognition},
  author={Nicola Pluchino and Panagiotis Drakopoulos and Francesco Bianchi-Demicheli and Jean Marie Wenger and Patrick Petignat and Andrea R Genazzani},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},

Novel mechanisms for DHEA action.

This review summarizes the molecular mechanisms by which D HEA acts in cells and animal models with a focus on the 'novel' and physiological modes of DHEA action.

Cortisol and DHEA in development and psychopathology

Is DHEA replacement beneficial in chronic adrenal failure?

Oestrogens and Progestagens: Synthesis and Action in the Brain

The present review summarises some of the studies related to the synthesis and function of oestrogens and progestagens in the central nervous system.

Effect of dehydroepiandrosterone on the liver of perimenopausal rat: multiple doses study

Long-term administration of high doses of DHEA causes ultrastructural alterations and changes in the levels of cholesterol and triglyceride in hepatocytes of perimenopausal rats.

The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health

  • M. Alemany
  • Biology
    International Journal of Molecular Sciences
  • 2022
The clinical use of T to correct hypoandrogenism helps maintain the functionality of core metabolism, limiting excess fat deposition, sarcopenia and cognoscitive frailty and the effectiveness of using lipophilic T esters for T replacement treatments is analyzed in depth, and the main problems derived from their application are discussed.

Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women - position statement of expert panel of Polish Menopause and Andropause Society.

It is concluded that currently available clinical trials and meta-analyses indicate that DHEA supplementation is effective in women with adrenal insufficiency and chronically treated with exogenous glucocorticoids, postmenopausal women with low bone mineral density and/or osteoporosis, premenopausalWomen with sexual disorders and low libido, and in Women with vulvovaginal atrophy due to menopause or genitourinary syndrome ofMenopause.



Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women.

Increases in mental and physical sexual arousal ratings significantly increased in response to an acute dose of DHEA in postmenopausal women.

Dehydroepiandrosterone (DHEA) treatment of depression

Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue.

A number of biological indices confirmed the lack of harmful consequences of this 50 mg/day DHEA administration over one year, indicating that this kind of replacement therapy normalized some effects of aging, but does not create "supermen/women" (doping).

Neurosteroids in depression: a review

Indirect genomic and non-genomic mechanisms are involved in the neurosteroidogenic pathophysiology of depression and several findings support the hypothesis of an antidepressant effect of allopregnanolone.

Dehydroepiandrosterone is an anxiolytic in mice on the plus maze.

The hypothesis that neurosteroids could be involved in the termination of a stress response is supported by the effects of these compounds in mice on motor activity and behavior in the elevated plus maze.

Is dehydroepiandrosterone a hormone?

The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women's health at menopause.