Neurobiology of DHEA and effects on sexuality, mood and cognition

@article{Pluchino2015NeurobiologyOD,
  title={Neurobiology of DHEA and effects on sexuality, mood and cognition},
  author={Nicola Pluchino and Panagiotis Drakopoulos and Francesco Bianchi-Demicheli and Jean Marie Wenger and Patrick Petignat and Andrea R Genazzani},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2015},
  volume={145},
  pages={273-280}
}

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The present review summarises some of the studies related to the synthesis and function of oestrogens and progestagens in the central nervous system.

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Long-term administration of high doses of DHEA causes ultrastructural alterations and changes in the levels of cholesterol and triglyceride in hepatocytes of perimenopausal rats.

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Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women - position statement of expert panel of Polish Menopause and Andropause Society.

It is concluded that currently available clinical trials and meta-analyses indicate that DHEA supplementation is effective in women with adrenal insufficiency and chronically treated with exogenous glucocorticoids, postmenopausal women with low bone mineral density and/or osteoporosis, premenopausalWomen with sexual disorders and low libido, and in Women with vulvovaginal atrophy due to menopause or genitourinary syndrome ofMenopause.
...

References

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Increases in mental and physical sexual arousal ratings significantly increased in response to an acute dose of DHEA in postmenopausal women.

Dehydroepiandrosterone (DHEA) treatment of depression

Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue.

A number of biological indices confirmed the lack of harmful consequences of this 50 mg/day DHEA administration over one year, indicating that this kind of replacement therapy normalized some effects of aging, but does not create "supermen/women" (doping).

Neurosteroids in depression: a review

Indirect genomic and non-genomic mechanisms are involved in the neurosteroidogenic pathophysiology of depression and several findings support the hypothesis of an antidepressant effect of allopregnanolone.

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The hypothesis that neurosteroids could be involved in the termination of a stress response is supported by the effects of these compounds in mice on motor activity and behavior in the elevated plus maze.

Is dehydroepiandrosterone a hormone?

The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women's health at menopause.
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