Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

  title={Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders},
  author={Michael J. Notaras and Maarten van den Buuse},
  journal={Molecular Psychiatry},
Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and remains one of the most prominently studied molecules within psychiatry. Stress, which arguably remains the “lowest common denominator” risk factor for several mental illnesses, targets BDNF in disease-implicated brain regions and circuits. Altered stress-related responses have also been observed in animal… 
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The BDNF level in the blood serum of individuals with a past psychotraumatic event serves as a predictor of the level of expressiveness of resistance to stress and the formation of evidence base for clinical psychology and improvement of approaches to diagnostics.
Brain-derived Neurotrophic Factor: a Key Gene Risk Factor and Potential Therapy Target in Bipolar Disorder
BD epidemiology, symptoms, BDNF structure, and its action of function are summarized and various mechanisms of BDNF Val66Met and Arg125Met variant for BD pathogenesis in detail are reviewed and insights into possible BD clinical treatment targets are provided.
NDT_A_256278 1555..1560
Several studies have shown that BDNF levels are lower in the cerebrospinal fluid, plasma, serum, platelets, and brain in patients with MDD than in healthy controls, and most of these studies reported that decreased BDNF Levels are reversed in those who responded to antidepressants compared with those who were remittent to antidepressants.
Early-life stress effects on BDNF DNA methylation in first-episode psychosis and in rats reared in isolation
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Genetic variation and BDNF levels in plasma of the subjects with PTSD were significantly higher than those in the non-PTSD controls, agreeing with evidence suggesting that BDNF is involved in the development of PTSD.
Genetic Variants of the Brain-Derived Neurotrophic Factor and Metabolic Indices in Veterans With Posttraumatic Stress Disorder
It is revealed that BDNF Val66Met and C270T were not significantly associated with metabolic indices in veterans with PTSD and that these genetic variants do not contribute to susceptibility to metabolic disturbances in PTSD.
Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants
It is found that heterozygous BDNF+/Met mice displayed hypothalamic-pituitary-adrenal axis hyperreactivity, increased depressive-like and anxiety-like behaviors, and impaired working memory compared with WT mice after 7 d restraint stress, suggesting selective behavioral, molecular, and structural deficits resulting from the interaction between stress and the human genetic BDNFMet polymorphism.
Early Life Stress Effects on Glucocorticoid—BDNF Interplay in the Hippocampus
The effects of ELS paradigms on GC- and BDNF-dependent mechanisms and their crosstalk in the hippocampus are addressed, including potential implications for the pathogenesis of common stress-related disorders.
Are BDNF and glucocorticoid activities calibrated?
Physiology of BDNF: focus on hypothalamic function
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Findings are consistent with the correlation of depression and anxiety, yet suggest that partially differentiated gene–brain cognition pathways to these syndromes can be identified, even in a nonclinical sample, and may aid establishing an evidence base for more tailored intervention strategies.
No association between the brain‐derived neurotrophic factor gene Val66Met polymorphism and post‐traumatic stress disorder
The findings suggest that the BDNF polymorphism investigated herein does not play a major role in the susceptibility to PTSD at least in the Korean population, and further studies designed to explore the relationship between genetic variations of BDNF and the incidence of PTSD in a larger population may be warranted.
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