Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

  title={Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders},
  author={M. Notaras and M. van den Buuse},
  journal={Molecular Psychiatry},
  • M. Notaras, M. van den Buuse
  • Published 2020
  • Medicine
  • Molecular Psychiatry
  • Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and remains one of the most prominently studied molecules within psychiatry. Stress, which arguably remains the “lowest common denominator” risk factor for several mental illnesses, targets BDNF in disease-implicated brain regions and circuits. Altered stress-related responses have also been observed in animal… CONTINUE READING

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