Neurobiology: A move to sort life from death

  title={Neurobiology: A move to sort life from death},
  author={David R Kaplan and F. D. Miller},
The death of nerve cells is a key aspect in the establishment of functional neural circuits during development, but inevitably also features in injury or degenerative conditions. On page 843 of this issue, Nykjaer et al. provide some surprising molecular insights into cellular demise. Two unrelated cell-surface proteins, the p75 neurotrophin receptor (p75NTR) and sortilin, collaborate to induce death in responsive cells — including neurons. This joint effort involves direct interactions between… CONTINUE READING


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