Neurobiology: A move to sort life from death

@article{Kaplan2004NeurobiologyAM,
  title={Neurobiology: A move to sort life from death},
  author={David R Kaplan and F. D. Miller},
  journal={Nature},
  year={2004},
  volume={427},
  pages={798-799}
}
The death of nerve cells is a key aspect in the establishment of functional neural circuits during development, but inevitably also features in injury or degenerative conditions. On page 843 of this issue, Nykjaer et al. provide some surprising molecular insights into cellular demise. Two unrelated cell-surface proteins, the p75 neurotrophin receptor (p75NTR) and sortilin, collaborate to induce death in responsive cells — including neurons. This joint effort involves direct interactions between… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

The Neurotrophins and Their Role in Alzheimer’s Disease

Current neuropharmacology • 2011
View 18 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…