Neurobiological model of obsessive–compulsive disorder: Evidence from recent neuropsychological and neuroimaging findings

@article{Nakao2014NeurobiologicalMO,
  title={Neurobiological model of obsessive–compulsive disorder: Evidence from recent neuropsychological and neuroimaging findings},
  author={Tomohiro Nakao and Kayo Okada and Shigenobu Kanba},
  journal={Psychiatry and Clinical Neurosciences},
  year={2014},
  volume={68}
}
Obsessive–compulsive disorder (OCD) was previously considered refractory to most types of therapeutic intervention. There is now, however, ample evidence that selective serotonin reuptake inhibitors and behavior therapy are highly effective methods for treatment of OCD. Furthermore, recent neurobiological studies of OCD have found a close correlation between clinical symptoms, cognitive function, and brain function. A large number of previous neuroimaging studies using positron emission… 
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References

SHOWING 1-10 OF 124 REFERENCES
Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder
TLDR
A model is presented which describes how frontal-subcortical brain circuitry may mediate OCD symptomatology, and a hypothesis for how successful treatments may ameliorate symptoms, via their effects on circuit activity is suggested.
Predictors of treatment response to fluvoxamine in obsessive-compulsive disorder: an fMRI study.
Brain Corticostriatal Systems and the Major Clinical Symptom Dimensions of Obsessive-Compulsive Disorder
Working memory dysfunction in obsessive-compulsive disorder: a neuropsychological and functional MRI study.
Neuropsychological performance in obsessive-compulsive disorder: a critical review
Functional MRI study of brain activation alterations in patients with obsessive–compulsive disorder after symptom improvement
Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies.
TLDR
It is suggested that activations within the dorsal frontoparietal network might be related to patients' efforts to resist the obsessive processes induced by the provocation task.
...
...