Neurobiological effects of intraventricular propionic acid in rats: Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders

@article{MacFabe2007NeurobiologicalEO,
  title={Neurobiological effects of intraventricular propionic acid in rats: Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders},
  author={D. MacFabe and D. Cain and Karina Rodr{\'i}guez-Capote and Andrew E. Franklin and K. Ossenkopp},
  journal={Behavioural Brain Research},
  year={2007},
  volume={176},
  pages={149-169}
}
  • D. MacFabe, D. Cain, +2 authors K. Ossenkopp
  • Published 2007
  • Biology, Medicine
  • Behavioural Brain Research
  • Clinical observations suggest that certain gut and dietary factors may transiently worsen symptoms in autism spectrum disorders (ASD), epilepsy and some inheritable metabolic disorders. Propionic acid (PPA) is a short chain fatty acid and an important intermediate of cellular metabolism. PPA is also a by-product of a subpopulation of human gut enterobacteria and is a common food preservative. We examined the behavioural, electrophysiological, neuropathological, and biochemical effects of… CONTINUE READING
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