Neurobiological and pharmacological validity of curcumin in ameliorating memory performance of senescence-accelerated mice.

@article{Sun2013NeurobiologicalAP,
  title={Neurobiological and pharmacological validity of curcumin in ameliorating memory performance of senescence-accelerated mice.},
  author={Chen-you Sun and Shuang S Qi and Kejian Deng and Huai R Cui and Shi Xi Chen and Kai Yu Dai and Mao L Tang},
  journal={Pharmacology, biochemistry, and behavior},
  year={2013},
  volume={105},
  pages={76-82}
}
The senescence-accelerated mouse prone 8 (SAMP8 mice) is known as a neurodegenerative model and may show age-related deficits of cognition. Curcumin, a major active component of spic turmeric, could increase the capacity of learning and memory in the aged rat. However, it is not known whether curcumin could improve cognitive deficits in SAMP8 mice. The present study was undertaken to evaluate the effect of curcumin on the learning and memory of SAMP8 mice and its possible mechanisms. Subjects… CONTINUE READING
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