Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism.

@article{Durazzo2007NeurobiologicalAN,
  title={Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism.},
  author={Timothy C. Durazzo and Dieter J. Meyerhoff},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2007},
  volume={12},
  pages={
          4079-100
        }
}
  • T. Durazzo, D. Meyerhoff
  • Published 1 May 2007
  • Medicine, Psychology
  • Frontiers in bioscience : a journal and virtual library
Chronic cigarette smoking is associated with adverse effects on cardiac, pulmonary, and vascular function as well as the increased risk for various forms of cancer. However, little is known about the effects of chronic smoking on human brain function. Although smoking rates have decreased in the developed world, they remain high in individuals with alcohol use disorders (AUD) and other neuropsychiatric conditions. Despite the high prevalence of chronic smoking in AUD, few studies have addressed… 

Tables from this paper

Chronic Cigarette Smoking: Implications for Neurocognition and Brain Neurobiology

A review of the peer-reviewed literature on the neurocognitive and neurobiological implications of chronic cigarette smoking in cohorts that were not seeking treatment for substance use or psychiatric disorders finds that chronic smoking appears to be associated with deficiencies in executive functions, cognitive flexibility, general intellectual abilities, learning and/or memory processing speed, and working memory.

Smoking, nicotine and neuropsychiatric disorders

Effects of cigarette smoking and alcohol use on neurocognition and BDNF levels in a Chinese population

The results suggest that smoking is associated with cognitive decline, but not with BDNF levels in a normal population, however, smoking severity is positively associated withBDNF levels.

Interactive effects of chronic cigarette smoking and age on brain volumes in controls and alcohol‐dependent individuals in early abstinence

The findings indicate that consideration of smoking status is necessary for a better understanding of the factors contributing to regional brain atrophy in AUD.

Neurocognition in 1-month-abstinent treatment-seeking alcohol-dependent individuals: interactive effects of age and chronic cigarette smoking.

The age-related findings suggest that the combination of active chronic smoking and alcohol dependence in this 1-month-abstinent ALC cohort was associated with greater than normal age- related effects in multiple domains.

Brain-behavior relations and effects of aging and common comorbidities in alcohol use disorder: A review.

Evidence for AUD-aging interactions, indicative of accelerated aging, together with increasing alcohol consumption in middle-age and older adults, put aging drinkers at special risk for developing cognitive decline and possibly dementia.

Chronic cigarette smoking in alcohol dependence: associations with cortical thickness and N‐acetylaspartate levels in the extended brain reward system

This dual modality magnetic resonance (MR) study indicated that chronic smoking in ALC was associated with significant cortical thinning and NAA abnormalities in anterior brain regions that are implicated in the development and maintenance of addictive disorders.

Chronic alcohol consumption, abstinence and relapse: brain proton magnetic resonance spectroscopy studies in animals and humans.

An overall assessment of the MRS research literature on brain alcohol effects, the role of animal and human studies in understanding the disease, and the need of widely integrative MRS studies of cohorts that include individuals with comorbidies that are reflective of the general population with AUD are discussed.
...

References

SHOWING 1-10 OF 295 REFERENCES

Smoking is associated with neurocognitive deficits in alcoholism.

Quantitative brain MRI in alcohol dependence: preliminary evidence for effects of concurrent chronic cigarette smoking on regional brain volumes.

Preliminary evidence is provided that comorbid chronic cigarette smoking accounts for some of the variance associated with cortical gray matter loss and appears to alter relationships between brain structure and cognitive functions in alcohol-dependent individuals.

Cigarette smoking exacerbates chronic alcohol-induced brain damage: a preliminary metabolite imaging study.

Human in vivo proton magnetic resonance spectroscopic imaging findings indicate that chronic cigarette smoking exacerbates chronic alcohol-induced neuronal injury and cell membrane damage in the frontal lobes of RAs and has independent adverse effects on neuronal viability and cell membranes in the midbrain and on cell membranes of the cerebellar vermis.

Effects of chronic alcohol dependence and chronic cigarette smoking on cerebral perfusion: a preliminary magnetic resonance study.

Preliminary evidence is provided that chronic cigarette smoking adversely affects cerebral perfusion in frontal and parietal GM of 1-week-abstinent alcohol-dependent individuals, in line with spectroscopic and structural magnetic resonance studies that suggest chroniccigarette smoking compounds the detrimental effects of alcohol dependence on brain neurobiology.

Functional brain imaging of tobacco use and dependence.

  • A. Brody
  • Biology, Psychology
    Journal of psychiatric research
  • 2006

Nicotine and Cognitive Efficiency in Alcoholics and Illicit Stimulant Abusers: Implications of Smoking Cessation for Substance Users in Treatment

It is suggested that nicotine may modify cognitive efficiency in alcoholics and illicit stimulant abusers, a concept with relevance to both the design of experimental work and the treatment of alcohol and illicit Stimulant dependence.

Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders

The current understanding of central nicotinic acetylcholine receptor (nAChRs) systems in normal and neuropsychiatric disease states and their role with respect to cognitive dysfunction and clinical symptoms in several specific neuroPsychiatric populations, including ADHD, Alzheimer's disease, Parkinson's Disease, Tourette's Disorder, schizophrenia and affective disorders is reviewed.
...