Neurobiological and Clinical Effects of the Antidepressant Tianeptine

  title={Neurobiological and Clinical Effects of the Antidepressant Tianeptine},
  author={Siegfried Kasper and Bruce S. McEwen},
  journal={CNS Drugs},
The precise neurobiological processes involved in depression are not clear, but it is recognized that numerous factors are involved, including changes in neurotransmitter systems and brain plasticity. Neuroplasticity refers to the ability of the brain to adapt functionally and structurally to stimuli. Impairment of neuroplasticity in the hippocampus, amygdala and cortex is hypothesized to be the mechanism by which cognitive function, learning, memory and emotions are altered in depression. The… 
Neuroplasticity and major depression, the role of modern antidepressant drugs.
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  • Psychology, Biology
    World journal of psychiatry
  • 2012
The neuroplasticity hypothesis may explain the therapeutic and prophylactic action of ADs representing a new innovative approach to the pathophysiology of depression and stress-related disorders.
Molecular regulation of the hippocampal neurogenic niche in depression and by antidepressants: Insights from an unpredictable Chronic Mild Stress rat model
A validated rat model of depression, the unpredictable chronic mild stress (uCMS), is used to explore the molecular underpinnings of neural plasticity in the hippocampal DG (hDG), in the context of depression and antidepressant treatment, finding that all antidepressants were able to reverse the depressive-like profile and the dendritic plasticity impairments induced by uCMS.
Synaptic plasticity in the pathophysiology and treatment of bipolar disorder.
It is concluded that increased serotonin, norepinephrine, dopamine, brain-derived neurotrophic factor (BDNF), acute corticosterone, and antidepressant treatments lead to enhanced synaptic strength in the hippocampus and also correlate with antidepressant-like behaviors.
Studies on antidepressant-mediated regulation of signal transduction
It is shown that the atypical antidepressant tianeptine can potentiate signaling cascades associated with synaptic plasticity and add further evidence that tIANeptine acts as an enhancer of AMPA glutamate transmission.
Glutamate-Mediated Neuroplasticity Deficits in Mood Disorders
The goal of this chapter is to focus on glutamate’s role in neuroplasticity in brain structures associated with regulation of mood and emotional behaviors, with particular emphasis on psychiatric illnesses such as major depressive disorder.
Regulation of Cellular Plasticity in Mood Disorders: The Role of the AMPA Receptor
Improved understanding of the neural mechanisms involved in mood disorders has led to the development of several major classes of antidepressant agents, all of which block either the oxidation of monoamine neurotransmitters or their reuptake by neurons.
Tianeptine: An Antidepressant with Memory-Protective Properties
Findings indicate that tianeptine accomplishes its anti-stress effects by normalizing stress-induced increases in glutamate in the hippocampus and amygdala, which is potentially relevant to recent research which indicates that abnormalities in glutamatergic neurotransmission are involved in the pathogenesis of depression.
The neurobiological properties of Tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation
Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, which could provide a key pathway for its antidepressant action, and therefore offer new insights into how tianptine may be useful in the treatment of depressive disorders.
From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder
The evidence challenging the monoamine hypothesis is summarized and proposed that the antidepressant efficacy of SSRIs is not derived from elevated monoamine (5-HT, noradrenaline (NE), or dopamine (DA) concentration or monoamine neurotransmission.
Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression


Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
A Neurotrophic Model for Stress-Related Mood Disorders
Regulation of Cellular Plasticity Cascades in the Pathophysiology and Treatment of Mood Disorders
A growing body of data suggests that the glutamatergic system—which is known to play a major role in neuronal plasticity and cellular resilience—may be involved in the pathophysiology and treatment of mood disorders.
Preclinical research on stress, memory, and the brain in the development of pharmacotherapy for depression
Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine
The schema underlying the effect of tianeptine on central plasticity is the most thoroughly studied of any antidepressants, and insights into how compounds like tianptine may be useful in the treatment of neurobiological features of depressive disorders are offered.
Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex
Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy
Experimental and clinical data demonstrating that stress and antidepressant treatments affect neurogenesis in opposite direction in rodents supports the view that neuroplastic phenomena are involved in the physiopathology of depression and underlie—at least partly—antidepressant therapy.
Neuroimaging studies of mood disorders
  • W. Drevets
  • Psychology, Medicine
    Biological Psychiatry
  • 2000
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
  • B. Czéh, T. Michaelis, E. Fuchs
  • Psychology, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
The effect of tianeptine, a modified tricyclic antidepressant, in the chronic psychosocial stress model of adult male tree shrews, a model with high validity for research on the pathophysiology of major depression, is investigated.
Neural plasticity: consequences of stress and actions of antidepressant treatment
  • R. Duman
  • Psychology, Biology
    Dialogues in clinical neuroscience
  • 2004
The literature is presented demonstrating altered plasticity in response to stress, and evidence that chronic antidepressant treatment can reverse or block the effects, and even induce neural piasiicity-iike responses.