Neurobiological adaptations to psychostimulants and opiates as a basis of treatment development.

@article{Sevarino2000NeurobiologicalAT,
  title={Neurobiological adaptations to psychostimulants and opiates as a basis of treatment development.},
  author={Kevin A. Sevarino and Alison H Oliveto and Thomas R. Kosten},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={909},
  pages={
          51-87
        }
}
Abuse of illicit substances, in particular psychostimulants and opiates, is a worldwide public health issue. Chronic use of cocaine and amphetamine causes common neurobiological adaptations that may guide new treatment development. These include perturbations in dopamine and serotonin neurotransmission, leading to trials of antidepressants, and serotonin and dopamine augmentation strategies. The detection of cerebral perfusion abnormalities caused by psychostimulants has led to examination of… CONTINUE READING