Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder

@article{Milad2009NeurobiologicalBO,
  title={Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder},
  author={Mohammed R. Milad and Roger K. Pitman and Cameron B. Ellis and Andrea L. Gold and Scott L. Rauch},
  journal={Biological Psychiatry},
  year={2009},
  volume={66},
  pages={1075-1082}
}
BACKGROUND A clinical characteristic of posttraumatic stress disorder (PTSD) is persistently elevated fear responses to stimuli associated with the traumatic event. The objective herein is to determine whether extinction of fear responses is impaired in PTSD and whether such impairment is related to dysfunctional activation of brain regions known to be involved in fear extinction, viz., amygdala, hippocampus, ventromedial prefrontal cortex (vmPFC), and dorsal anterior cingulate cortex (dACC… CONTINUE READING

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