Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic.

@article{Zhang2015NeurobehaviouralAI,
  title={Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic.},
  author={M Q Zhang and M. H. Ji and Qian Zhao and Min Jia and L L Qiu and Yong Guang Peng and J J Yang and Anatoly E. Martynyuk},
  journal={British journal of anaesthesia},
  year={2015},
  volume={115 5},
  pages={752-60}
}
BACKGROUND We tested the hypothesis that developmental effects of repeated neonatal exposure to sevoflurane in rats are exacerbated by stressful experiences received later in life. METHODS Sprague-Dawley male rats received sequential exposures to 3% sevoflurane for two h on postnatal days (P) six, seven, and eight. After weaning at P21, rats were housed either in pairs in an enriched environment (EE) or singly in an enrichment-deprived environment (an adverse environment, AE). The hippocampal… CONTINUE READING
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