Neurobehavioral actions of coumestrol and related isoflavonoids in rodents.

  title={Neurobehavioral actions of coumestrol and related isoflavonoids in rodents.},
  author={Patricia L. Whitten and Heather B. Patisaul and Larry E. Young},
  journal={Neurotoxicology and teratology},
  volume={24 1},
Isoflavonoids are plant estrogens that are increasingly advocated as a natural alternative to estrogen replacement therapy (ERT) and are available as dietary supplements. As weak estrogen agonists/antagonists with a range of other enzymatic activities, the isoflavonoids provide a useful model for the actions of endocrine disruptors. This paper reviews the responses of rodents to diets containing coumestrol or an isoflavone supplement in comparison to animals fed the phytoestrogen-free AIN76A… CONTINUE READING