Neurobehavioral Characteristics of Mice with Modified Intermediate Filament Genes

  title={Neurobehavioral Characteristics of Mice with Modified Intermediate Filament Genes},
  author={Robert Lalonde and Catherine Strazielle},
  journal={Reviews in the Neurosciences},
  pages={369 - 386}
Intermediate proteins comprise cytoskeletal elements that preserve the shape and structure of neurons. These proteins have been proposed to be involved in the onset and progression of amyotrophic lateral sclerosis (ALS), mainly characterized by motoneuron atrophy and paresis. In support of this hypothesis are the findings that genetically modified mice for intermediate filaments successfully mimic certain neuropathological aspects of ALS, such as reduced axonal caliber and retarded conduction… 

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