Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease.

@article{Teipel2006NeuroanatomyOD,
  title={Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease.},
  author={Stefan J. Teipel and Harald Hampel},
  journal={Behavior genetics},
  year={2006},
  volume={36 3},
  pages={405-15}
}
Aging in Down syndrome (DS) is accompanied by neuropathological features of Alzheimer's disease (AD). Therefore, DS has been proposed as a model to study predementia stages of AD. MRI-based measurement of grey matter atrophy is an in vivo surrogate marker of regional neuronal density. A range of neuroimaging studies have described the macroscopic neuroanatomy of DS. Recent studies using sensitive quantitative measures of region-specific atrophy based on high-resolution MRI suggest that age… CONTINUE READING