Neuroanatomy of Down's syndrome: a high-resolution MRI study.

  title={Neuroanatomy of Down's syndrome: a high-resolution MRI study.},
  author={Joseph D. Pinter and Stephan Eliez and J. Eric Schmitt and George T Capone and Allan L. Reiss},
  journal={The American journal of psychiatry},
  volume={158 10},
OBJECTIVE Down's syndrome, the most common genetic cause of mental retardation, results in characteristic physical and neuropsychological findings, including mental retardation and deficits in language and memory. This study was undertaken to confirm previously reported abnormalities of regional brain volumes in Down's syndrome by using high-resolution magnetic resonance imaging (MRI), determine whether these volumetric abnormalities are present from childhood, and consider the relationship… CONTINUE READING


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